Aghdashloo had not been planning a return to acting, but a friend convinced her to read a play he'd written about a man accused of being a member of the Shah's elite. Thrown out of the country, the man wants to commit suicide right in front of Big Ben by the River Thames to highlight what is going on in Iran. She was so moved by the play that she agreed to take part, deciding that she could touch people and make them politically aware through her acting. The play was a big success and even toured the United States, ending up in Los Angeles. When the show wrapped, Aghdashloo attended a play written by Iranian actor/playwright Houshang Touzie. She was moved by the play, and found herself falling in love with Touzie, but returned to London, believing that she had to concentrate on her political ideals rather than marry. However, she finally realized that Touzie, who had also studied at the drama workshop in Iran, shared many of her political ideals and when he asked her to return to Los Angeles, she did. They were married in 1987 and run a theater company together.

One day, while she was watching the television show Oprah, a book called House of Sand and Fog was featured. She bought it and immediately identified with the character of Nadi, a wife and mother. Having appeared in several small budget independent films, she was called in to audition almost three years later and impressed the casting agents and director so much that they couldn't imagine anyone else in the role. Starring Ben Kingsley (as her husband) and Jennifer Connelly, House of Sand and Fog (2003) would be Aghdashloo's highest profile film to date. She not only won numerous awards for her performance, including a Los Angeles Film Critics Association award, New York Film Critics Circle award and an Online Film Critics Society award, but received her first Oscar nomination.